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It binds to BRPF1B with a Kd of 13 nM (ITC)
InChiKey: FAZZYPIBZBGQSH-UHFFFAOYSA-N
Meeting: 2011 ASCO Annual Meeting
It plays a critical role in regulating synaptic plasticity and neural network activity
WS3 - β Cell Proliferation Inducer. CAS# 1421227-52-2 60302 It binds to BRPF1B withWS3, CAS No. 1421227 52 2, is a highly potent and selective small molecule that promotes pancreatic cell and RPE cells expansion, identified by a high throughput, cell based screening. It can induce proliferation of mouse R7T1 cells with an EC50 ~0. 074 M, and expansion of primary rat and human cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and adult human