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with IC50 values between 0
MCB-613 (6-8 μM
InChi: InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18
COC1C=C(C=C(OC)C=1OC)C(=O)O[C@@H]1C[C@@H]2CN3CCC4C5=CC=C(C=C5NC=4[C@H]3C[C@@H]2[C@@H]([C@H]1OC)C(=O)OC)OC
D77 ram sodium salt with IC50 values between 0D77 is anti HIV 1 inhibitor targeting the interaction between integrase and cellular LEDGF p75. D77 inhibits HIV 1(IIIB) replication by EC50 value of 23. 8 g ml in MT 4 cell (5. 03 g ml for C8166 cells). IC50 value: 23. 8 g ml (EC50, in MT 4 cell ), 5. 03 g ml (EC50, in C8166 cell)Target: HIV 1in vitro: D77 exhibits a highly specific binding affinity to HIV 1 integrase catalytic core domain. D77 induces a dramatic concentration dependent decrease of
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