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CID 25010775
2379438-80-7
WO2015092740A1
Mechanistic studies revealed that NSC319726 restores WT structure and function to the p53R175 mutant
PQR-309 - CAS# 1225037-39-7 0216 CID 25010775PQR 309, CAS No. 1225037 39 7, is an orally bioavailable pan inhibitor of phosphoinositide 3 kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K mTOR kinase inhibitor PQR 309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K mTOR. Activation of
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