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5-8 hours) results in a concentration-dependent reduction of ErbB2 receptor phosphorylation
may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels
a NAD(+)-dependent deacetylase involved in the regulation of energy homeostasis and the modulation of various metabolic pathways
CAS Number: 154039-60-8
Tankyrase-IN-2 Catalog No.:M14406-2 5-8 hours) results in aTankyrase IN 2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase IN 2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model. Product information CAS Number: 1588870 36 3 Molecular Weight: 316. 30 Formula: C17H14F2N2O2 Chemical Name: 6,8 difluoro 2 [4 (2