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M22 (15-30 μM
4-phenylenebis(methylene))bis(pyrimidin-2-amine)
2015 Apr 1
TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells
Pimethixene maleate nic Acid M22 (15-30 μMPimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5 HT2A, 5 HT2B, 5 HT2C, 5 HT1A, 5 HT1B, 5 HT6, 5 HT7, Adrenergic 1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4. 4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.
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