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Midostaurin inhibits protein kinase C alpha (PKCalpha)
Seladelpar sodium salt also significantly reduces sirius red-positive areas in foz/foz mice (P<0
15R)-10-(3
3 mL/kg/min
BI-9627 Catalog No.:M21408-C Midostaurin inhibits protein kinase CBI 9627 is potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI 9627 displays >30 fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI 9627 shows low DDI (drug drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart