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PubMed Central PMCID: PMC3104103
30)/t17-/m1/s1
18-Dibenzyl-3
Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently
BSJ-03-123 rescein Diacetate PubMed Central PMCID: PMC3104103BSJ 03 123 is a Selective Cdk6 degrader. BSJ 03 123 exploits protein interface determinants to achieve proteome wide selectivity for the degradation of cyclin dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.
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