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borrowed from Magic: The Gathering is the concept of life points, and if a player in either game reaches 0 life points, they lose

Narcomoeba is also a may effect, and while it is unlikely you would want to decline using it, there are corner-case scenarios where you may want to play around Anger of the Gods and leave your Prized Amalgams in the graveyard

I wasn't a serious tournament player, and I wasn't a Timmy

While this could change at some point in the future, especially if Wizards of the Coast actually puts the work into MTG Arena to allow new formats in the game, we're not expecting that to be the case any time soon