LB-100 Catalog No.:M8527-10 Poeschke O

Poeschke O

with novel features that make it a promising compound for the therapy and prophylaxis of all forms of theileriosis

PubMed PMID: 24023282

compound list : BAY-87-2243

LB-100 Catalog No.:M8527-10 Poeschke OLB 100 is a protein phosphatase 2A(PP2A)inhibitor. LB 100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. LB 100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments. LB 100 dramatically increased intracellular p Smad3 level, which was responsible for the effect of LB 100 as a sensitizer. LB 100 downregulated Bcl 2 expression and enhanced sorafenib