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263:102-111
16)14-10-12-6-1-7-13-10
5-3(6)1-2-4(7)8/h2*10-11
166(2):453-9
Trabectedin D3 Size:Contact [email protected] for quotation 263:102-111Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF 7 and MDA MB 453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer
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