Tyk2-IN-5 ino pyrazole is a activin receptor-like kinase-2

is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1

1-4 hours) significantly increases cleaved caspase-3 levels

Formula: C13H8N2O3

CRA-026440 inhibits pure recombinant isozymes HDAC1

Tyk2-IN-5 ino pyrazole is a activin receptor-like kinase-2Tyk2 IN 5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0. 086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFN. Highly effective in inhibiting IFN production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. Product information CAS Number: 1797432 62 2 Molecular Weight: 434. 43 Formula: C21H19FN8O2 Chemical Name: N [(1R,2S) 2 fluorocyclopropyl] 8