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CALP3 causes dose-dependent inhibition of apoptosis (IC50=33
It was developed in Spain by FAES Farma
It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively)
reducing capabilities and Fe2+ chelating effects
TAK-659 3992 CALP3 causes dose-dependent inhibition ofTAK 659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3. 2 nM and 4. 6 nM for SYK and FLT3, respectively. TAK 659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL). Product information CAS Number: 1312691 33 0 Molecular Weight: 344. 39 Formula:
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