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AZ5104 display minimal off-target activity against other non-HER family kinases
Su-11274 exhibits a selective inhibition pattern toward different receptor mutated variants
PubMed PMID: 10762053
2015 Jun 15
UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S AZ5104 display minimal off-target activityUF 010, CAS No. 537672 41 6, is a Class I HDAC inhibitor (IC50 values are 0. 06, 0. 1, 0. 5 and 1. 5 M for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological
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