AP14145 hydrochloride Size:Contact [email protected] for quotation 3-bis(2-amino-2-oxoethyl)-9-benzyl-21

3-bis(2-amino-2-oxoethyl)-9-benzyl-21

4-d]pyrimidin-6-yl}phenyl)-2-methylmorpholine-4-carboxamide

Chemical Name: 7-oxo-7H-benzo[de]benzo[4

InChiKey: DGGQUKOLHQXDLV-QTNXRKSWSA-N

AP14145 hydrochloride Size:Contact [email protected] for quotation 3-bis(2-amino-2-oxoethyl)-9-benzyl-21AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1. 1 M for KCa2. 2 (SK2) and KCa2. 3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant resistant porcine model of atrial fibrillation (AF). Product