Icotinib Hydrochloride - CAS# 1204313-51-8 Size:Solid 10 mg Activation of mTORC1 (indicated by

Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM)

This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators

Battershill JM

2*1-2(3)4/h6-7

Icotinib Hydrochloride - CAS# 1204313-51-8 Size:Solid 10 mg Activation of mTORC1 (indicated byIcotinib, also known as BPI 2009, is an orally available quinazoline based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Icotinib selectively inhibits the wild type and several mutated forms of EGFR tyrosine kinase. This may lead to an inhibition of EGFR mediated signal transduction and may inhibit cancer cell proliferation. EGFR, a receptor tyrosine kinase, is upregulated in a variety of cancer cell