Cetirizine dihydrochloride thine HCl H2O HER-2 (IC50 19 nM) and

HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM)

SCH-442416 (0

4R)-5-(pyridin-2-yl)-2

Smiles: CC(C)N(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C1CC(C1)CCC1NC2=CC=C(C=C2N=1)C(C)(C)C

Cetirizine dihydrochloride thine HCl H2O HER-2 (IC50 19 nM) andCetirizine hydrochloride is a potent second generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen induced asthma. Cetirizine hydrochloride is a carboxylated metabolite of hydroxyzine that acts as a selective Histamine H1 receptor inverse agonist. Compared to its parent compound, it shows similar antihistaminic activity, but with greater H1 selectivity and less sedative effects.