![PF-00356231 hydrochloride inyl urea O=[P@@]1([S-])O[C@@H]2[C@H]3CO[P@@](=O)([S-])O[C@@H]4[C@@H](CO1)O[C@H]([C@@H]4F)[N@@]1C=NC4=C1N=CN=C4NCC=CCNC1=NC=NC4=C1N=C[N@]4[C@H](O3)[C@@H]2F |t:35|](https://cdn.shopify.com/s/files/1/0389/1897/9723/files/1688462095629.png?v=1688462119)
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O=[P@@]1([S-])O[C@@H]2[C@H]3CO[P@@](=O)([S-])O[C@@H]4[C@@H](CO1)O[C@H]([C@@H]4F)[N@@]1C=NC4=C1N=CN=C4NCC=CCNC1=NC=NC4=C1N=C[N@]4[C@H](O3)[C@@H]2F |t:35|
Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate
PF-3644022 blocks TNFα and IL-6 production in LPS-stimulated human whole blood with IC50 values of 1
PubMed PMID: 20003343
PF-00356231 hydrochloride inyl urea O=[P@@]1([S-])O[C@@H]2[C@H]3CO[P@@](=O)([S-])O[C@@H]4[C@@H](CO1)O[C@H]([C@@H]4F)[N@@]1C=NC4=C1N=CN=C4NCC=CCNC1=NC=NC4=C1N=C[N@]4[C@H](O3)[C@@H]2F |t:35|PF 00356231 hydrochloride is a specific, non peptidic, non zinc chelating ligand and inhibitor of matrix metalloproteinase MMP 12 (IC50=1. 4 M). PF 00356231 hydrochloride binds to MMP 12 and forms PF 00356231 MMP 12 complex. PF 00356231 hydrochloride shows potency against MMP 13, MMP 8, MMP 9, MMP 3 with IC50s of 0. 00065, 1. 7, 0. 98, 0. 39 M, respectively. Product information CAS Number: 820223 77 6 Molecular Weight: 464. 96 Formula: C25H21ClN2O3S