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EI546 sodium
PubMed Central PMCID: PMC3562069
with virtually complete inhibition at 10 μM
Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle
RGB-286638 free base anaxatriol EI546 sodiumRGB 286638 is a multitargeted cyclin dependent kinase inhibitor. RGB 286638 triggers P53 dependent and independent anti multiple myeloma activity through inhibition of transcriptional CDKs. GB 286638 treatment resulted in MM cytotoxicity in vitro associated with inhibition of MM tumor growth and prolonged survival in vivo. RGB 286638 displayed caspase dependent apoptosis in both wt p53 and mutant p53 cells that was closely associated with the