Z-DQMD-FMK 17517 In NCI-H345 cells possessing CCKB/gastrin

In NCI-H345 cells possessing CCKB/gastrin receptors

CAS Number: 581073-80-5

18-pentahydroxy-7-[(4-hydroxyphenyl)methyl]-13-[(1H-indol-3-yl)methyl]-1

CAS Number: 1141777-14-1

Z-DQMD-FMK 17517 In NCI-H345 cells possessing CCKB/gastrinInhibition of caspase 3 processing by Z DQMD FMK (Z Asp(OMe) Gln Met Asp(OMe) fluoromethylketone) did not restore cell number in the zinc deficient group, but resulted in processing of full length PKC to a 56 kDa fragment1. The inhibitory effect of specific caspase inhibitors (Z DQMD FMK, Z IETD FMK and Z LEHD FMK) suggests that the MG132 induced apoptotic cell death and depletion of GSH in SCLC cells are mediated by both activation of caspase 8 and