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The SB202190 group also shows significantly reduced neuronal apoptosis in the hippocampus compared to VaD model rats (P<0
001 versus vehicle)
Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents
It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion
ALX-1393 27420 The SB202190 group also showsALX 1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model. Product information CAS Number: 949164 09 4 Molecular Weight: 395. 42 Formula: C23H22FNO4 Chemical Name: (2S) 2 amino 3 {[2 (benzyloxy)phenyl](3 fluorophenyl)methoxy}propanoic acid Smiles: N[C@@H](COC(C1=CC=CC=C1OCC1C=CC=CC=1)C1=CC(F)=CC=C1)C(O)=O InChiKey: ADUSZEGHFWRTQS AIBWNMTMSA N InChi: InChI=1S
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