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17(12):1282-94
The soluble epoxide hydrolase (sEH) can convert epoxides to the corresponding diols by the catalytic addition of a water molecule
noncompetitive and orally available autotaxin inhibitor
6-bis[(pyrrolidin-1-yl)methyl]cyclohexa-2
2-Ethyl-5, 7-dimethyl-3H-imidazo[4, 5-b]pyridine 7632 hydrochloride 17(12):1282-942 Ethyl 5,7 dimethyl 3H imidazo[4,5 b]pyridine is a nonpeptidic angiotensin II receptor antagonist. Angiotensin II is the critical pressor substance of the renin angiotensin system (RAS). The angiotensin II system, a proteolytic cascade regulating hemodynamics and water and electrolyte balance, is able to contribute to hypertensive states in human. The effects of the octapeptide angiotensin I1 includs cardiac stimulation, vasoconstriction, stimulation
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