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Epub 2015 Aug 11
NSC 348884
InChiKey: BVZLLUDATICXCI-JMSCDMLISA-N
Jończyk J
NVP-231 - CAS# 362003-83-6 ticancer activities Epub 2015 Aug 11NVP 231, CAS No. 362003 83 6, is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP 231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide, resulting in decreased endogenous C1P levels. When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP 231 synergistically increased ceramide levels and reduced
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