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Smiles: O=C1C=C(OC(=C1)N1CCOCC1)C1=CC=CC2SC3=CC=CC=C3SC=21
20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5
administration of Dasatinib at doses as high as 300 mg/kg has no effect on survival time
Y Hagihara
WEHI-539 - CAS# 1431866-33-9 lunine Smiles: O=C1C=C(OC(=C1)N1CCOCC1)C1=CC=CC2SC3=CC=CC=C3SC=21WEHI 539 is a highly potent and selective BCL XL inhibitor. The prosurvival BCL 2 family protein BCL X(L) is often overexpressed in solid tumors and renders malignant tumor cells resistant to anticancer therapeutics. WEHI 539 has high affinity (subnanomolar) and selectivity for BCL X(L) and potently kills cells by selectively antagonizing its prosurvival activity. WEHI 539 will be an invaluable tool for distinguishing the roles of BCL X(L) from those
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