INCA-6 Size:Contact [email protected] for quotation Smiles: OC(CN1C=NC=N1)(CN1C=NC=N1)C1=CC=C(F)C=C1F

Smiles: OC(CN1C=NC=N1)(CN1C=NC=N1)C1=CC=C(F)C=C1F

5 mg/mL (49

Valimaki MJ

and IL-15 with IC50 values of 244

INCA-6 Size:Contact [email protected] for quotation Smiles: OC(CN1C=NC=N1)(CN1C=NC=N1)C1=CC=C(F)C=C1FINCA 6 is a selective inhibitor of transcription factor NFAT with Kd value of 0. 8 mM in vitro. NFAT (Nuclear factor of activated T cells) is a general name which is applied to a family of transcription factors that are important in immune response. They are expressed in most immune system cells. Calcium signaling plays an important role in NFAT activation. Calmodulin activates calcineurin (CN) which is a serine threonine phosphatase, then