(S)-PFI-2 (hydrochloride) xypicolinic acid Chemical Name: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide hydrate hydrochloride

Chemical Name: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide hydrate hydrochloride

IC50 approximately 5μM)

BCAT-IN-1 (compound 8b) inhibits BCATm in human cells

33 mg/mL (225

(S)-PFI-2 (hydrochloride) xypicolinic acid Chemical Name: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzamide hydrate hydrochloride(S) PFI 2 (hydrochloride) is the inactive enantiomer of (R) PFI 2 and may serve as a negative control. (R) PFI 2 is a cell permeable and potent SET7 9 inhibitor with IC50 value of 2 nM . Protein methyltransferases involve in the epigenetic regulation of gene transcription, silencing, chromatin structure establishment, maintenance, DNA repair, and replication. SET domain containing (lysine methyltransferase) 7 (SETD7) (SET9; SET7 9, KMT7) is a protein