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THAL-SNS-032 induces rapid degradation of CDK9 without affecting the levels of other SNS-032 targets
Chemical Name: 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-6-(trifluoromethyl)-1H-1
Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96
InChi: InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3
LMT-28 ycyrrhetinic acid THAL-SNS-032 induces rapid degradation ofLMT 28 is an orally active and the first synthetic IL 6 inhibitor that functions through direct binding to gp130. LMT 28 shows low toxicity and selectively inhibits IL 6 induced phosphorylation of STAT3, JAK2, and gp130. Product information CAS Number: 1239600 18 0 Molecular Weight: 311. 42 Formula: C17H29NO4 Chemical Name: (4S) 3 [(2S,3S) 3 hydroxy 2 methyl 4 methylidenenonanoyl] 4 (propan 2 yl) 1,3 oxazolidin 2 one Smiles:
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