JNK Inhibitor VIII ramide A (NPI-0052) and orally available pan-Akt inhibitor

and orally available pan-Akt inhibitor

2-a]pyrazin-3(7H)-one

Pelitinib treatment significantly inhibits the autophosphorylation of EGFR but not c-Met in A431 cells

is a potent b-Raf inhibitor

JNK Inhibitor VIII ramide A (NPI-0052) and orally available pan-Akt inhibitorJNK Inhibitor VIII (TCS JNK 6o) is an inhibitor of c Jun N terminal kinases with IC50 of 45 nM and 160 nM for JNK 1 and JNK 2, respectively. JNK Inhibitor VIII (TCS JNK 6o) inihibits JNK 1, JNK 2, and JNK 3 with Ki of 2 nM, 4 nM and 52 nM, respectively. Product information CAS Number: 894804 07 0 Molecular Weight: 356. 38 Formula: C18H20N4O4 Synonym: TCS JNK 6o Chemical Name: N (4 Amino 5 cyano 6 ethoxy 2 pyridinyl) 2,5 dimethoxybenzeneacetamide