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SC-26196 did not affect the conversion of [1-14C]20:3n-6 to 20:4 in the fibroblasts
2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
MCF-7 breast and A-549 NSCL cancer xenografts
PubMed PMID: 18791063
CFI-402257 HCl, MPS1/TTK 0099 SC-26196 did not affect theCFI 402257 is an orally bioavailable inhibitor of monopolar spindle 1 (MPS1 TTK) kinase (IC50 = 1. 7 nM). CFI 402257 is selective for MPS1 TTK over a panel of 262 kinases at a concentration of 1 M. CFI 402257 increases aneuploidy in HCT116 cells when used at concentrations greater than 100 nM. It inhibits cell growth in a panel of breast, ovarian, prostate, pancreatic, lung, and colon cancer cell lines (GI50s = 0. 001 1. 3 M). CFI 402257 (6. 5 mg kg)
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