![GNF-6231 0636457-O-C3-COOH ¹⁸]icosan]-18'-eneoxy]-5-{[(3R](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M20551_1635202021.gif?v=1635202022)
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¹⁸]icosan]-18'-eneoxy]-5-{[(3R
InChiKey: WSYRBHQWMXTCHQ-UHFFFAOYSA-N
Smiles: CC1=NN(C2=CC(NCCCOCCOCCOCCOCCOCCCNCC3C=CC(=CC=3)/C(/C=C/C3=[N+](CCCCS([O-])(=O)=O)C4=CC=CC=C4C3(C)C)=C\C=C3\N(CCCCS(O)(=O)=O)C4=CC=CC=C4C\3(C)C)=C(C=C2)C(N)=O)C2CC(C)(C)CC(=O)C1=2
Chemical Name: methyl N-[(2S)-1-[(6S)-6-[5-(9
GNF-6231 0636457-O-C3-COOH ¹⁸]icosan]-18'-eneoxy]-5-{[(3RGNF 6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. 1) GNF 6231 shows IC50s of greater than 10 M on all CYP isoforms tested2) GNF 6231 have favorable potency and a PK profile across preclinical species upon oral administration. 3) The reference for orally in MMTV Wnt1 tumor bearing mice is dosed at 3 mg kg. 4) GNF 6231 showed very robust dose related antitumor efficacy. Product information CAS
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