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N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 CAS Number: 182431-12-5

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Description

CAS Number: 182431-12-5

(2010) ACS Med

org/wiki/Monomethyl_auristatin_E

(2011) Cancer Lett

N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 CAS Number: 182431-12-5N106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart

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